Scientists cracks how can prevent painkillers from spreading cancer

Scientists believe that they have come to know how cheap pain relievers can stop spreading aspirin cancer.

In animal experiments, he revealed that the drug enhanced the ability of the immune system to fight back.

The Cambridge University team said it was an exciting and surprising discovery that can eventually prescribe the drug to cancer patients – but not yet and people are advised just to take bullets.

Regular aspirin comes with risks and the tests are still trying to find out which patients are likely to benefit the most.

Tentalize data from More than a decade ago It was shown that those who were already taking a daily aspirin were more likely to survive when suffering from cancer.

But how?

It appears to be focused at a moment of vulnerability for a cancer – when a lonely cell breaks from the original tumor and tries to spread elsewhere in the body, like a seed on the air.

This process is called metastasis and is the reason Most deaths From cancer.

A part of our immune rescue – a white blood cell called T -Sail – can swoop and destroy the spreading cancer as it tries to take the root.

But the study showed that another part of our blood – platelets that usually prevent bleeding – were pressing T -cells and making them difficult to get cancer out.

Aspirin disrupts platelets and removes its effect on T-cells so that they can hunt cancer.

Prof. Rahul Roychodhuri of Cambridge University told me: “What we have discovered is that aspirin can work, surprisingly, by removing the power of the immune system to identify and kill cancer cells.”

They feel that drugs will work best in cancer that are caught early and can be used after treatment such as surgery to help the immune system find any cancer that can already spread.

The most natural question for anyone to ask cancer is whether they should take aspirin.

“If you are a cancer patient, do not yet participate in your local pharmacy to buy aspirin, but a surgeon and cancer researcher at London’s Queen Mary University, Prof. Mangesh Thorat, says,” Actively consider the participation of aspirin or participation in upcoming trials.

He says that the study had provided the “missing piece of Jigsaw puzzle” in understanding how the study has done “how aspirin has worked, but still had questions to respond.

Aspirin can cause dangerous internal bleeding, including stroke to balance risks. It is also not clear whether the effect works for all cancer or just specific. And this is still animal research while scientists feel that this will be applicable to those who will still need to be confirmed.

Some patients – with lynch syndrome, which increases the risk of cancer – already there Recommended aspirin,

But it will still take the appropriate clinical test to understand whether more patients will also benefit.

They are already running. Prof. Ruth Langley from MRC Clinical Trial Unit at University College London is leading Ad-Aspirin Trial To see if aspirin can prevent early stage cancer from returning.

He said that the results of the study were “an important discovery” because they would help working out “which is likely to benefit from aspirin after diagnosis of cancer”.

However, he warned of the risks of taking aspirin again and “always talk to your doctor before starting”.

For a long time, Professor Royachauduri suspects that new drugs will be developed which take the benefits of aspirin, but with low of risky side effects.

Search, Published in journal natureThe accident occurred because scientists were not doing research on Aspirin.

The team in Cambridge was investigating how the immune system responded to cancer when they spread.

They were genetically using engineer mice and found that people who lacked a specific set of genetic instructions were less likely to have metastatic cancer that spread.

Further investigation revealed how those T-cells were being suppressed and it began to overlap with how aspirin was known to work in the body.

Dr. who carried out research, Dr. Zee Yang said: “It was an Eureka moment.

“It was a completely unpredictable discovery that sent us a separate route of investigation, as we guessed.”