AI is trained to recognize warning signs in blood tests

This is the third feature in a six-part series looking at how AI is changing medical research and treatment.

Ovarian cancer is “rare, underfunded and deadly”, says Audra Moran, head of the Ovarian Cancer Research Alliance (OCRA), a New York-based global charity.

Like all cancers, the earlier it is detected the better.

Most ovarian cancer starts in the fallopian tubes, so by the time it reaches the ovaries, it has spread elsewhere.

“You may have to detect ovarian cancer five years before any symptoms appear to have an impact on mortality,” says Ms Moran.

But new blood tests are emerging that use the power of artificial intelligence (AI) to detect signs of cancer in its early stages.

And it’s not just cancer, AI can also speed up other blood tests for potentially deadly infections like pneumonia.

Dr. Daniel Heller is a biomedical engineer at Memorial Sloan Kettering Cancer Center in New York.

His team has developed a testing technique that uses nanotubes – tiny tubes of carbon that are about 50,000 times smaller than the diameter of a human hair.

About 20 years ago, scientists began exploring nanotubes that could emit fluorescent light.

Over the past decade, researchers learned how to change the properties of these nanotubes so that they respond to almost anything in the blood.

It’s now possible to insert millions of nanotubes into a blood sample and have them emit different wavelengths of light depending on what’s stuck to them.

But there still remains the question of interpreting the signal, which Dr. Heller compares to finding a match for a fingerprint.

The fingerprint in this case is a pattern of molecules binding to the sensor, with different sensitivities and binding strengths.

But the patterns are too subtle for humans to recognize.

“We can look at the data and not make sense of it,” he says. “We can only see patterns that are different with AI.”

Decoding the nanotube data means loading the data into a machine-learning algorithm, and telling the algorithm which samples came from patients with ovarian cancer, and which from people without cancer.

These included blood from people with other types of cancer, or other gynecological disease, which could be confused with ovarian cancer.

A major challenge in using AI to develop a blood test for ovarian cancer research is that it is relatively scarce, which limits the data for training algorithms.

And even much of that data is hidden within the hospitals where they are treated, with minimal data shared with researchers.

Dr. Heller describes training the algorithm on the available data from a few 100 patients as a “Hail Mary pass.”

But he says the AI ​​was able to achieve better accuracy than the best cancer biomarkers available today – and that was just the first attempt.

Further study on the system is underway to see if it can be improved using a larger set of sensors and many more patient samples. More data can improve algorithms, just as algorithms for self-driving cars can improve with more testing on the road.

Dr. Heller has high hopes for the technology.

“What we want to do is test all gynecological diseases – so when someone comes in with a complaint, can we give doctors a tool that will tell them immediately whether it’s more likely to be cancer or not? Or worse, it’s cancer.”

Dr. Heller says this could take “three to five years.”

Not only is AI potentially useful for early detection, but it’s also speeding up other blood tests.

For a cancer patient, contracting pneumonia can be fatal and, since there are approximately 600 different organisms that can cause pneumonia, doctors have to perform many tests to identify the infection.

But new types of blood tests are making the process simpler and faster.

Karuis, based in California, uses artificial intelligence (AI) to help identify the exact pneumonia pathogen in 24 hours and select the right antibiotic for it.

Alec Ford, chief executive of Karius, says, “Before our test, a patient with pneumonia would have to undergo 15 to 20 different tests to identify their infection in their first week in hospital – a test costing about $20,000. Will be.”

Carius has a database of microbial DNA containing tens of billions of data points. Test samples from patients can be compared to that database to identify the exact pathogen.

Mr Ford says this would have been impossible without AI.

One challenge is that researchers do not currently understand all the connections that an AI test can make between biomarkers and diseases.

Over the past two years Dr. Slavey Petrovsky has developed an AI platform called Milton, which identifies 120 diseases with a success rate of over 90% using biomarkers in UK Biobank data.

Finding patterns in data on such a large scale can only be done by AI.

“These are often complex patterns, where there may not be one biomarker, but you have to take into account the whole pattern,” says Dr. Petrovsky, a researcher at pharmaceutical giant AstraZeneca.

Dr. Heller uses a similar pattern matching technique in his work on ovarian cancer.

“We know that the sensor binds and reacts to proteins and small molecules in the blood, but we don’t know which proteins or molecules are specific to cancer,” he says.

More broadly, data, or the lack of it, is still a drawback.

“People aren’t sharing their data, or there aren’t mechanisms in place to do so,” Ms. Moran says.

Ocra is funding a large-scale patient registry, containing electronic medical records of patients, that has allowed researchers to train algorithms on their data.

“It’s early days yet – we’re still in the Wild West of AI,” says Ms Moran.